5D Library › Molecules and Terroir · 中文

Chapter 7 The Classical Materia Medica

Place, season and drying

The Shennong Bencao Jing (神农本草经, Divine Farmer’s Classic of Materia Medica), compiled around the beginning of the common era and now known from later reconstructions, opens with general rules. One sentence could stand as the epigraph of this book.

Source text

药有酸咸甘苦辛五味,又有寒热温凉四气,及有毒无毒,阴干暴干,采造时月,生熟,土地所出,真伪陈新,并各有法。(顾观光 辑 1956)

“Drugs have the five tastes, sour, salty, sweet, bitter and pungent, and the four qi, cold, hot, warm and cool, and are toxic or non-toxic. Drying in the shade or in the sun, the time of harvest and preparation, raw or processed, the land where they grow, genuine or false, old or new: each has its rule.” (Shennong Bencao Jing, general preface)

Every variable that the earlier chapters of this book have measured is in that list: the land (Chapter 1), the time of harvest (Chapter 2’s age and season), drying in shade or sun (Chapters 3 and 5), raw or processed (Chapter 3’s gingerol and shogaol), genuine or false and old or new (Chapter 6’s identity tests and storage). What the classical texts did not have was a way to measure them.

Shihu: the upper grade

The Shennong Bencao Jing sorts its 365 drugs into three grades. The upper grade holds substances regarded as nourishing and safe for long use. Shihu (石斛, Dendrobium) is among them.

Source text

石斛,味甘,平。主伤中,除痹,下气,补五脏虚劳羸瘦,强阴。久服厚肠胃,轻身,延年。(顾观光 辑 1956; 谢清华 et al. 2026)

“Shihu: sweet, neutral. It governs damage to the centre, removes impediment, lowers qi, supplements the five organs in depletion, fatigue and emaciation, and strengthens yin. Taken for a long time it thickens the stomach and intestines, lightens the body and prolongs life.”

Two later texts add what the classic leaves out: where the plant grows and how it is dried.

Source text

生六安山谷、水傍石上。七月、八月采茎,阴干。(陶弘景 撰;尚志钧 辑校 1986; 谢清华 et al. 2026)

“It grows in the mountain valleys of Lu’an, on rocks beside water. Gather the stems in the seventh and eighth months and dry them in the shade.” (Mingyi Bielu, Supplementary Records of Famous Physicians)

In the Bencao Gangmu (本草纲目), completed in 1578, Li Shizhen gathered earlier writers’ notes on each drug. Under shihu he preserved the Song-dynasty scholar Su Song’s list of places where it was found, which includes “Wenzhou and Taizhou” (温州、台州) on the Zhejiang coast (李时珍 著;刘衡如、刘山水 校注 2011; 郑亚倩 et al. 2024). Yueqing, where the Yandang Mountains stand, lies within today’s Wenzhou.

The Mingyi Bielu’s instruction, shade-drying, is interesting in the light of Chapter 5. Shade-drying is slow and cool. It spares heat-sensitive compounds, but a stem that stays moist for weeks risks mould. Later processing texts record another approach: the Leigong Paozhi Lun has the stems “soaked in wine for a night, then steamed with ghee” (用酒浸一宿,却用酥蒸) (谢清华 et al. 2026). Modern producers who twist fresh stems into fengdou spirals and dry them over gentle heat are following a third path.

Dried ginger: the middle grade

Dried ginger (干姜, ganjiang) is in the middle grade of the Shennong Bencao Jing, the group of drugs regarded as useful for treating conditions but needing more care, not in the upper grade.

Source text

干姜,味辛,温。主胸满咳逆上气,温中止血,出汗,逐风湿痹,肠澼下利。生者尤良。(顾观光 辑 1956; Xu et al. 2023)

“Dried ginger: pungent, warm. It governs fullness in the chest, cough and counterflow qi, warms the centre and stops bleeding, promotes sweating, expels wind-damp impediment, and treats diarrhoea. The fresh one is especially good.”

The last phrase, “the fresh one is especially good”, is a reminder that the classical authors knew fresh and dried ginger were different materials. Li Shizhen describes how dried ginger was made and judged.

Source text

干姜,以母姜造之……以白净结实者为良,故人呼为白姜。(李时珍 著;刘衡如、刘山水 校注 2011; 张嘉鑫 et al. 2018)

“Dried ginger is made from the mother rhizome … the white, clean and firm is best, which is why people call it white ginger.”

“White, clean and firm” is a description of quality that a modern grader could still use: free of soil and mould, not shrivelled or hollow. It also hints that the best dried ginger was not dark, which in modern terms suggests limited browning during drying.

Shade, sun and oven, by calculation

Traditional texts distinguish drying in the shade (阴干), in the sun (晒干 or 暴干) and over a fire or in an oven (焙干). The kinetics of Chapter 3 can put rough numbers on what each does to the balance between gingerol and shogaol.

Calculation

Share of the gingerol–shogaol pair present as shogaol after four drying schedules, using the rate constants fitted in Chapter 3. Because those constants were measured at pH 1, only the comparison between schedules is meaningful, not the absolute numbers. Real drying also changes water content as it proceeds, which the model ignores.

import math

R = 8.314
# Arrhenius constants fitted in Chapter 3 to Bhattarai et al. (2001), pH 1.
# Ginger tissue is far less acidic, so only the comparison between
# schedules means anything here, not the absolute numbers.
EA_F, LNA_F = 75_050, 22.624            # gingerol → shogaol
EA_R, LNA_R = 51_840, 14.870            # shogaol → gingerol

def shogaol_after(steps, s=0.0):
    """Share of the pair present as shogaol after (°C, hours) steps."""
    for t, hours in steps:
        T = t + 273.15
        kf = math.exp(LNA_F - EA_F / (R * T))
        kr = math.exp(LNA_R - EA_R / (R * T))
        eq = kf / (kf + kr)
        s = eq + (s - eq) * math.exp(-(kf + kr) * hours)
    return s

methods = {
    "shade-dried, 28 °C for 10 days":          [(28, 240)],
    "sun-dried, 4 × (40 °C 8 h + 26 °C 16 h)": [(40, 8), (26, 16)] * 4,
    "oven-dried, 70 °C for 8 h":               [(70, 8)],
    "freeze-dried, −25 °C 20 h + 25 °C 8 h":   [(-25, 20), (25, 8)],
}
for name, steps in methods.items():
    s = shogaol_after(steps)
    print(f"{name:41s} shogaol {100 * s:4.1f} %, "
          f"gingerol : shogaol = {(1 - s) / s:4.0f} : 1")
# shade-dried, 28 °C for 10 days            shogaol 10.4 %, gingerol : shogaol =    9 : 1
# sun-dried, 4 × (40 °C 8 h + 26 °C 16 h)   shogaol  7.8 %, gingerol : shogaol =   12 : 1
# oven-dried, 70 °C for 8 h                 shogaol 15.9 %, gingerol : shogaol =    5 : 1
# freeze-dried, −25 °C 20 h + 25 °C 8 h     shogaol  0.4 %, gingerol : shogaol =  264 : 1

The result is not what a quick guess would give. Ten days of shade-drying at a warm 28 °C produces more shogaol than four days of sun-drying with hotter afternoons, because time counts as well as temperature; this agrees with the experimental finding in Chapter 3 that drying time mattered more than air temperature for gingerol loss. An oven at 70 °C for eight hours converts more still. Freeze-drying converts almost nothing. Each tradition of processing was, in effect, choosing a point on this scale, and the classical preference for different preparations of ginger for different purposes (fresh, dried, and later charred 炮姜) corresponds to real chemical differences.

Daodi: the proper region

The idea of daodi (道地) medicinal materials, those from the regions recognised over centuries as the best sources, is the Chinese counterpart of terroir. Historical research on Dendrobium officinale traces how its recognised regions shifted over time, and how both place and processing were thought to shape quality (郑亚倩 et al. 2024).

Note

The classical texts are records of observation and practice, written within a system of ideas (the five tastes, the four qi, the organs) that is not the system of modern chemistry or medicine. When the Shennong Bencao Jing says that shihu taken long “thickens the stomach and intestines”, that is a traditional statement, not evidence of an effect in people as a randomised trial would understand it. This chapter reads the classics for what they noticed about place, harvest and processing, which modern methods can test, and makes no health claim from them.

Hypothesis · not established

Not established. Among traditional drying methods for ginger, the duration of drying explains more of the variation in the gingerol-to-shogaol ratio of the product than the maximum temperature does, for maximum temperatures up to 70 °C. The hypothesis would be refuted if, in a designed comparison that varies duration and temperature independently, maximum temperature explained more of the variation than duration.

References

Xu, Xiao-xue, Sheng Guo, Er-xin Shang, et al. 2023. “基于 r 语言数据挖掘的姜-枣药对配伍特点及组方规律分析.” 中草药 54 (11).
张嘉鑫, 顾然, 郭宇, 王庆国, and 魏玮. 2018. “半夏泻心汤之方药考.” 长春中医药大学学报 34 (1): 182–85. https://doi.org/10.13463/j.cnki.cczyy.2018.01.059.
李时珍 著;刘衡如、刘山水 校注. 2011. 本草纲目(校点本). 华夏出版社.
谢清华, 马林纳, 于文俊, and 樊新荣. 2026. “石斛的历史源流、产业现状与发展策略.” 中草药 57 (17): 6998–7009. https://doi.org/10.7501/j.issn.0253-2670.2026.17.029.
郑亚倩, 曾慧婷, 余炅, 王小青, and 虞金宝. 2024. “铁皮石斛历史沿革及品质形成研究进展.” 世界科学技术—中医药现代化 26 (2).
陶弘景 撰;尚志钧 辑校. 1986. 名医别录(辑校本). 人民卫生出版社.
顾观光 辑. 1956. 神农本草经. 人民卫生出版社.

Fan, Y. (2026). Molecules and Terroir: Polysaccharides of Dendrobium officinale, Gingerols of Zingiber officinale, A-Type Proanthocyanidins and the Mass Transfer of Freeze-Drying [本草的分子与风土] (Version 1.0.0). 5D Library. https://doi.org/10.5281/zenodo.23693057 · Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).